解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Previously used only as a screening tool, cytology now emerges as a powerful diagnostic technique, especially since the advent of the fine needle aspiration (FNA) biopsy. This article highlights the use of ancillary techniques, primarily electron microscopy (EM), and immunohistochemistry (IHC). When coupled with routi...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(98)90003-x
更新日期:1998-12-01 00:00:00
abstract::Esophageal cancer is one of the most fatal cancers worldwide and is characterized by great variation in rates among different populations. Linxian, a county in Henan Province, located in north-central China, has one of the highest rates of esophageal squamous cell carcinoma in the world. Most squamous cell carcinomas ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90260-x
更新日期:1998-11-01 00:00:00
abstract::The molecular pathology of 20 lymphomas, which presented as testicular masses in patients with no evidence of previous lymphoma, was analyzed. These lymphomas occurred in men with a median age of 69 years (range, 37 to 87 years). Nine of the 14 patients with follow-up died of lymphoma (median survival, 12 months). All...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90250-7
更新日期:1998-11-01 00:00:00
abstract::We herein report an 18-month-old girl who presented with a retroperitoneal mature teratoma that later developed into an endodermal sinus tumor. Her symptoms included an expanding abdominal girth. The serum levels of alpha-fetoprotein were moderately elevated. The excised specimen was a benign mature cystic retroperito...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90432-4
更新日期:1998-10-01 00:00:00
abstract::Papillary carcinoma of the breast is a variant of predominantly intraductal carcinoma characterized by a papillary growth pattern with fibrovascular support. Loss of heterozygosity (LOH) was evaluated at multiple chromosomal loci (including loci reported to show frequent genetic alterations in breast cancer) to determ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90422-1
更新日期:1998-10-01 00:00:00
abstract::Although the therapeutic outcome of osteosarcoma patients has improved dramatically within the last 20 years because of combined neoadjuvant chemotherapy and surgery, the problem of drug resistance remains. Thus far, markers that can predict the response to chemotherapy at the time of biopsy are not available. Heat sh...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90412-9
更新日期:1998-10-01 00:00:00
abstract::We compared the DNA content (DI) by cell image analysis with the karyotype and morphological phenotype of paraffin-embedded tissues from 51 spontaneous abortions. The study included 21 cases with triploid, 19 cases with diploid, and 11 cases with aneuploid (monosomic, trisomic, or mosaic) karyotype. Measurements were ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90209-x
更新日期:1998-09-01 00:00:00
abstract::A better knowledge of the biological aggressiveness of individual tumors could facilitate the selection of treatment in prostate cancer patients. This study assesses the influence of histological and molecular features in core needle biopsy specimens of prostate cancer on tumor-specific survival. Formalin-fixed core n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90199-x
更新日期:1998-09-01 00:00:00
abstract::Spindle cell squamous esophageal carcinomas are distinctive polypoid "biphasic" tumors in which the sarcoma-like phenotype usually predominates over the epithelial component. To biologically assess both phenotypes, we compared the tumoral proliferative activity and DNA ploidy between the two histological components of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90458-0
更新日期:1998-08-01 00:00:00
abstract::Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be a good target for studying the early events of lung tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations that often harbor activating mutations of the K-ras oncogen...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90448-8
更新日期:1998-08-01 00:00:00
abstract::Bfl-1, a member of the Bcl-2 gene family, blocks p53-mediated apoptosis and has oncogenic transforming activity. In normal tissues, the transcript of Bfl-1 is expressed abundantly in bone marrow and at a low level in several other tissues. In previous experiments, elevated expression of Bfl-1 was observed by Northern ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90282-9
更新日期:1998-07-01 00:00:00
abstract::Telomerase is a ribonucleoprotein that consists of a RNA component for synthesizing telomeric DNA repeats onto chromosome ends, so that telomere length can be maintained; telomerase activation in general signifies immortalization of cells. Because the telomerase activity of only a few cases of nonastrocytic gliomas an...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)80009-9
更新日期:1998-06-01 00:00:00
abstract::Telomerase is a ribonucleoprotein enzyme associated with cellular immortality and has been detected in the vast majority of adult tumors. Wilms tumor is a histologically diverse embryonal malignancy of childhood, and the histological features of Wilms tumor and its precursor lesion, the nephrogenic rest, recapitulate ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90072-7
更新日期:1998-05-01 00:00:00
abstract::Aberrant crypt foci (ACF) are one of the earliest putative preneoplastic, and in some cases, neoplastic lesions in human colons. These microscopic lesions, identified on methylene blue-stained mucosa with a low-power-magnification microscope, are thought to be closely related to the earliest steps in multistage coloni...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90062-4
更新日期:1998-05-01 00:00:00
abstract::Villin (V) is a glycoprotein of microvilli associated with rootlet formation. Most colonic adenocarcinomas have a V positive (+), cytokeratin (CK) 20 (+), CK7-negative (-) immunophenotype; most lung adenocarcinomas have a CK20(-), CK7(+) immunophenotype. The reports of villin immunoreactivity in lung adenocarcinoma ra...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90121-6
更新日期:1998-04-01 00:00:00
abstract::We studied c-erbB-2, p53, and nm23 gene products in 112 primary breast carcinomas. Fifty patients were aged 35 years or younger, and 62 were aged 36 to 50. Clinicopathological criteria including clinical stage, hormone receptor status, histological types, histological grades, and lymph node status, were reviewed. Dise...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90111-3
更新日期:1998-04-01 00:00:00
abstract::To elucidate the putative role of human papillomavirus (HPV) infection in the etiology of esophageal cancer, 121 formalin-fixed, paraffin-embedded specimens originating from a non-high-incidence area for this carcinoma, from Slovenia, were screened for HPV infection using eight different polymerase chain reactions (PC...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/s0046-8177(98)90046-6
更新日期:1998-03-01 00:00:00
abstract::Extratubal secondary trophoblastic implants (ESTI) are a rare complication of conservative laparoscopic procedures for tubal ectopic pregnancies. These implants present with persistent beta-hCG titers postoperatively and are probably the result of disruption of the ectopic pregnancy at salpingostomy or morcellation of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90231-3
更新日期:1998-02-01 00:00:00
abstract::A critical area of chromosomal loss at region p16(9p21-22) and p53(17p13) has been implicated in the genesis of malignant melanoma. It is still unclear whether the genetic alterations can be detected in dysplastic nevus, a premalignant lesion of malignant melanoma. We have searched the frequency of p16 and p53 deletio...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90221-0
更新日期:1998-02-01 00:00:00
abstract::Pathological demonstration of varicella infection in first trimester aborted tissue is reported. A 24-year-old primigravida manifested chickenpox infection about 38 days after her last menstrual period or at 24 days age of the embryo. The conceptus survived another 4 to 5 weeks. The macerated embryo and placental tiss...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90396-3
更新日期:1998-01-01 00:00:00
abstract::The diagnosis of placental site trophoblastic lesions, particularly the distinction of a placental site trophoblastic tumor from an exaggerated placental site, can be difficult. Mel-CAM (also known as CD146 and MUC18) is a recently recognized cell adhesion molecule belonging to the immunoglobin gene superfamily that s...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(98)90386-0
更新日期:1998-01-01 00:00:00
abstract::Lymphangioleiomyomatosis (LAM) is a rare disease which afflicts young women of childbearing age. Recently, it has been listed as an indication for lung transplantation. We describe a case of recurrent LAM in a 31-year-old woman occurring in the allograft of a male donor after single lung transplantation. Nonisotopic i...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90233-1
更新日期:1997-12-01 00:00:00
abstract::Differentiation features and proliferation activity of 67 gastric microleiomyomas (microLMs) and 53 clinical gastrointestinal stromal tumors (GISTs) of the stomach were compared. The 67 microLMs were divided into two categories on the basis of cellularity: 53 hypocellular and 14 hypercellular types, and the 39 GISTs w...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90223-9
更新日期:1997-12-01 00:00:00
abstract::We have experienced an autopsy case of a 20-year-old woman with bronchiolitis obliterans, pemphigus vulgaris, and Castleman's disease. The affected bronchioles showed almost the same histology as previously described. But, the number of the lesions seemed too small to cause her death of respiratory insufficiency. We a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90208-2
更新日期:1997-11-01 00:00:00
abstract::Epidermal growth factor receptor (EGF-r) expression and tumor cell proliferation rate have been proposed as potential prognostic parameters in renal cell carcinoma (RCC). In this study, immunohistochemical stains using antibodies to EGF-r and the cell proliferation marker Ki-67 (MIB-1) were used to study the relations...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90198-2
更新日期:1997-11-01 00:00:00
abstract::A case of thymoma with associated opportunistic infections, CD4/CD8 T-lymphocyte imbalance, low CD4-positive T-lymphocyte counts and Kaposi's sarcoma (KS) without HIV infection is reported. Cytomegalovirus inclusions were identified in the nuclei of some KS spindle and endothelial cells. It is known that KS has a high...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90261-6
更新日期:1997-10-01 00:00:00
abstract::Computerized microscope morphometry was used to study cross sections from the vessels of the umbilical cord in placentas of patients with intrauterine growth retardation (IUGR) that displayed either normal or abnormal umbilical arteries (UA) Doppler flow velocity waveforms (FVW). Cords from 63 eutrophic fetuses with n...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90251-3
更新日期:1997-10-01 00:00:00
abstract::The striking differences in the histological features of gastric cancers in young and old adults have been thought to be related to differences in the biological behavior of these cancers. Recently, a new grading system (Goseki's classification) showed that the prognosis of the patient is particularly related to the m...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90059-9
更新日期:1997-09-01 00:00:00
abstract::The diagnosis of metastatic adenocarcinoma to the brain of unknown primary is problematic, and the role of immunohistochemistry in identifying a source has not been fully characterized. Sixty-eight metastatic adenocarcinomas of the brain with known primaries were immunostained with antibodies to cytokeratin 7 (CK7), c...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90009-5
更新日期:1997-08-01 00:00:00
abstract::Giant cell tumor of tendon sheath (GCTTS) is a common soft tissue tumor. Immunophenotypical evidence suggests it is of synovial cell origin. There is controversy regarding the underlying nature of this lesion, specifically whether it is a neoplastic or nonneoplastic (ie, reactive or hyperplastic) process. Karyotypic a...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90155-6
更新日期:1997-07-01 00:00:00
abstract::Recently, a novel tumor-associated protein, termed MN, has been described in carcinomas of the uterine cervix, where its expression has been shown to be associated with malignant transformation. Because malignant transformation in the esophagus develops through a dysplasia-carcinoma sequence similar to that which occu...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90185-4
更新日期:1997-06-01 00:00:00
abstract::Spindle cell carcinoma (SpCC) is uncommon, with a predilection for the upper aerodigestive tract. Its histogenesis has not been resolved, although most authors support the sarcomatoid carcinoma concept. Ploidy analysis and proliferation indices have not been reported for laryngeal SpCCs. The authors examined the patho...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90175-1
更新日期:1997-06-01 00:00:00
abstract::Endometrial carcinoma is the most common invasive malignancy of the female genital tract, and it exists as two different clinicopathologic forms: an estrogen-dependent, "usual" type and an estrogen-independent "special variant" type. Despite the frequency of endometrial cancer, little is known about the molecular gene...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90084-8
更新日期:1997-05-01 00:00:00
abstract::Posttransplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV), and may clinically resemble acute allograft rejection. Three methods to show EBV in tissue were evaluated in 15 liver allograft biopsies from 12 patients including four with PTLD: (1) semiquantitative polymerase chain react...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90074-5
更新日期:1997-05-01 00:00:00
abstract::Myocardial apoptosis has previously been observed in human acute myocardial infarcts. We examined the time of appearance and extent of apoptosis in human acute myocardial infarcts, and compared these with necrotic cell death. Because nuclear internucleosomal DNA fragmentation is a hallmark of apoptosis, autopsied tiss...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90039-3
更新日期:1997-04-01 00:00:00
abstract::Telomerase, the enzyme that stabilizes telomere length, is reactivated with almost all cancer types, and it may be necessary for unlimited cell proliferation. Assessment of malignancy in ordinary meningiomas is inconclusive because no clear-cut correlation exists between aggressive clinical behavior and histological f...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90029-0
更新日期:1997-04-01 00:00:00
abstract::We have previously reported that MUC2 apomucin was highly expressed in noninvasive tumors of the pancreas (intraductal papillary tumor [IdPT]) and liver (bile duct cystadenocarcinoma [BdCC]), which show more favorable outcomes than invasive carcinomas. In contrast, MUC2 was rarely expressed in invasive carcinomas of t...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90134-9
更新日期:1997-03-01 00:00:00
abstract::Demonstration of identical allelic loss on chromosome 11q13 in synchronous in situ (DCIS) and invasive ductal (IDC) breast carcinoma has provided molecular evidence of the progression of DCIS to IDC. We investigated loss of heterozygosity (LOH) at chromosome 11q13 in the spectrum of "marker/premalignant" and "malignan...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90124-6
更新日期:1997-03-01 00:00:00
abstract::Fetal vessels in the placentas of 11 of 15 infants with cerebral palsy contained thrombi. An alternate basis for the injury was identified in the four placentas without thrombi. Autopsy findings in one infant who died at age 1 month confirmed the presence of cerebral thrombi and infarcts. It is concluded that thrombot...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90114-3
更新日期:1997-02-01 00:00:00
abstract::Adamantinoma of long bones is a rare skeletal tumor of unknown origin with epithelial and fibrous elements. The ill-defined distinction between the two components in some cases earlier led to the assumption that these might be derived from the same (mesenchymal) stem cell. In this study, we investigated the distributi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/s0046-8177(97)90104-0
更新日期:1997-02-01 00:00:00